Familial aggregation of mandibular prognathism

Mandible in Mandibular Prognathism

Department of Orthodontics, School of Dentistry, National Taiwan University, Taipei; Department of Orthodontics, School of Dentistry, Kaohsiung Medical University, Kaohsiung; Institute of Biomechanical Engineering, National Cheng Kung University, Tainan. Received: 3 May 2002. Revised: 3 June 2002. Accepted: 9 July 2002. Reprint requests and correspondence to: Dr. Hong-Po Chang, Department of Or...

Candidate Gene Analyses of Mandibular Prognathism

Causation of a disease and a symptom generally is classified as genetic inheritance and environmental factors. A disease caused by a single gene disorder is defined as a disease that is attributed to a monogenic factor. A single gene disorder has been reported in more than 3,000 hereditary diseases. On the other hand, a polygenic or multifactorial disease is attributed to some susceptibility ge...

Chin cup therapy for mandibular prognathism.

Identification of a Mutation in FGF23 Involved in Mandibular Prognathism

Mandibular prognathism (MP) is a severe maxillofacial disorder with undetermined genetic background. We collected a Chinese pedigree with MP which involved in 23 living members of 4 generations. Genome-wide linkage analysis were carried out to obtain the information in this family and a new MP-susceptibility locus, 12pter-p12.3 was identified. Whole-exome sequencing identified a novel heterozyg...

Multidisciplinary treatment of mandibular prognathism with multiple congenitally missing teeth.

Surgical orthodontic treatment and dental implant therapy were performed on a man (aged 18 years 8 months) with mandibular prognathism and seven congenitally missing teeth: upper canines, first and second premolars and lower right second premolar. After 17 months of preoperative orthodontic treatment at age 20 years 1 month, sagittal split ramus osteotomy was performed using the remaining upper...